07:00 - 08:30 am

New Member Welcome Breakfast / Members Business Meeting
Room 4

Chemical Biology
CONCURRENT MORNING SYMPOSIA 1
Room 6 (room 5 - overflow)
08:30 Intro from Chair: Francisco Blanco, CIC bioGUNE. Elexalde Derio, Spain.

08:35 Edward Tate, Imperial College. London, United Kingdom.
Probing Dynamic Protein Lipidation: From Chemical Proteomics to Drug Discovery.

Young Investigator Speaker
09:05 Serena Zanzoni, University of Verona. Verona, Italy.
Ubiquitin-Nanoparticle Interactions by Solution NMR Spectroscopy.

09:20 Robert Copeland, Epizyme, Inc. Cambridge, MA, United States.
Protein Methyltransferase Inhibitors as Personalized Cancer Therapeutics.

09:50 25-min Coffee Break

10:15 Linda Hsieh-Wilson, California Institute of Technology/HHMI. Pasadena, CA, United States. 
Dynamic Regulation of Metabolic Enzymes and Pathways by O-Glycosylation.

Young Investigator Speaker
10:45 Maria Matveenko, University of Vienna. Vienna, Austria.
Semi-Chemical Synthesis and Characterization of a Small Heat Shock Protein Bearing a Nonenzymatic Posttranslational Modification Found In Vivo.

11:00 Ernest Giralt, Institut de Recerca Biomèdica. Barcelona, Spain. 
Peptides and Molecular Recognition at Protein Surfaces.

Folding
CONCURRENT MORNING SYMPOSIA 2
Auditorium

08:30 Intro from Chair: Irene Díaz-Moreno, Universidad de Sevilla CSIC. Sevilla, Spain.

08:35 John Christodoulou, University College London & Wellcome Trust. London, United Kingdom.
Structural Observations of Protein Folding on the Ribosome.

Young Investigator Speaker
09:05 Adrian Nickson, University of Cambridge. Cambridge, United Kingdom.
In Vitro Folding Mechanisms Determine the Forces Applied During Co-translational Folding.

09:20 Patricia Clark, University of Notre Dame. Notre Dame, IN, United States.
Folding to the Rhythm of Translation Rate.

09:50 25-min Coffee Break

10:15 Volker Dötsch, Johann Wolfgang Goethe Universität. Frankfurt am Main, Germany.
The unfolded N- and C-termini of TAp63a regulate p63's transcriptional activity by locking the protein in an inhibited, dimeric conformation.

Young Investigator Speaker
10:45 David Rodriguez-Larrea, University of the Basque Country. Leioa, Spain.
Single-molecule Vectorial Folding and Unfolding Through Membrane Pores.

11:00 Susan Buchanan, NIDDK, National Institutes of Health. Bethesda, MD, United States.
Structural Insight into the Biogenesis of Beta-Barrel Membrane Proteins.

11:30 am - 01:30 pm

Lunch
Poster Displays & Exhibits open – Exhibit Hall

Noon - 01:00 pm Mentoring Committee Workshop: How to Write an Effective Paper.
Room 3

Noon - 01:00 pm Educator's Luncheon: Using Primary Literature in the Classroom to Teach Foundational Concepts of Protein Science
Room 8

Exhibitor Lunch Workshop


Presented by Dr. Dan Some.
Noon - 01:00 pm Molar Mass, Size, Charge and Interactions: the Light Scattering Toolkit for Essential Biophysical Characterization and Quality Control.
Room 4

Protein Allostery & Dynamics
CONCURRENT AFTERNOON SYMPOSIA 1
Auditorium

01:30 Intro from Chair: Modesto Orozco, IRB Barcelona. Barcelona, Spain.

01:35 David Fushman, University of Maryland. College Park, MD, United States.
Deciphering the 'Ubiquitin Code': Conformations and Molecular Recognition of Polyubiquitin Signals..

Young Investigator Speaker
02:05 Anna Monica Nunes, Rutgers University. Newark, NJ, United States.
The Role of the Mg(II) Ion on Integrin-collagen Interactions: Regulating Affinity Through Conformational Fluctuations.

02:20 Patricia Bassereau, Institut Curie Centre de Recherche. Paris, France. 
Multifaceted BAR-domain Proteins to Shape Cell Membranes.

02:50 25-min Coffee Break

03:15 Jeanne Hardy, University of Massachusetts. Amherst, MA, United States.
Mapping Allosteric Sites Across the Apoptotic Caspases.

Protein Science Best Paper Speaker
03:45 Chih-Chia (Jack) Su, Iowa State University. Ames, IA, United States.
Crystal Structure of the Campylobacter Jejuni CmeC Outer Membrane Channel.

04:00 Harald Schwalbe, Johann Wolfgang Goethe Universität. Frankfurt am Main, Germany.
Allosteric Inhibition of FGF-FGFR-Complex by Small Molecules.

Engineering & Interpreting the Genome
CONCURRENT AFTERNOON SYMPOSIA 2
Room 6 (room 5 - overflow)

01:30 Intro from Chair: Maria Solà Vilarrubias, IRB Barcelona. Barcelona, Spain.

01:35 Osamu Nureki, University of Tokyo. Fukuoka, Japan.
Structural Basis for RNA-dependent DNA Cleavage and PAM Recognition by CRISPR-Cas9.

Young Investigator Speaker
02:05 Mahmoud Nasr, Harvard Medical School. Boston, MA, United States.
Creating Large Covalently Circularized Nanodiscs and Their Application in Studying Viral Entry and Genome Translocation.

02:20 Stanley Qi, University of California. San Francisco, CA, United States.
CRISPR Tools for Genome Engineering and Cell Reprogramming.

02:50 25-min Coffee Break

03:15 Luis Serrano, Centre for Genomic Regulation / ICREA. Barcelona, Spain.
Is it possible to understand in a quantitative manner a living system ?

Young Investigator Speaker
03:45 Can Kayatekin, Whitehead Institute. Cambridge, MA, United States.
Prion-like Proteins Sequester and Suppress the Toxicity of Huntingtin Exon 1.

04:00 Patricia Babbitt, University of California, San Francisco, CA, United States.
How Nature Evolves New Enzyme Functions.